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Are Randomized Control Trials suited for Mental Health research?

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Here are some limitations of using Randomized Control Trials (RCT) for Mental Health (MH) research. In the selection of people to RCTs, one needs to include subjects of a single condition or diagnostic category. However, in psychiatry the diagnosis can be unstable, changing, apart from secondary conditions, undiagnosed comorbid conditions. This also implies that the external validity of the RCT results are limited for MH.