My Perspective

My latest paper published in Biological Psychiatry: CNNi journal aimed to assess whether Mismatch Negativity (MMN) is reduced in early stage psychosis. MMN is an event-related potential that occurs when repetitive sounds are interrupted by an occasional sound that differs in frequency or duration. Many studies have shown that patients with schizophrenia are impaired in this process. Moreover, there is evidence that MMN-deficits may be present in early-stage psychosis.  To investigate this possibility, we employed Magnetoencephalography (MEG) to establish whether MMN-responses are impaired in participants at 116 Clinical High Risk for psychosis and 33 First Episode Psychosis Patients compared with 38 psychiatric controls and 49 healthy controls. Contrary to our hypothesis, MMN-responses were intact, suggesting that MMN may not constitute a biomarker for early detection and diagnosis of psychosis. Reference : [1] Pradeep D, et. al., "Intact Mismatch Negativity Responses in Clinical ...

In an article titled "Post-publication peer review: opening up scientific conversation", the inventors of and original advocates for open access now propose a radically new model of “publish first and then referee openly later” system. Faculty of 1000 ( F1000  London) where the author of this article belongs to, its remit is to work with named experts to identify and recommend the most interesting papers published across different subject areas in biology and medicine. Quoting the article, "Open access removes barriers for readers. Open, post-publication refereeing removes barriers for readers and authors alike, and it refocuses the role of peer review from, at its worst, a behind-the-scenes variety of censorship to, at its best, the process of expert criticism and advice that has always been its core and upon which the progress of science depends". What I liked most about the proposed model is its