MMN in early psychosis

My latest paper published in Biological Psychiatry: CNNi journal aimed to assess whether Mismatch Negativity (MMN) is reduced in early state psychosis.

MMN is an event-related potential that occurs when repetitive sounds are interrupted by an occasional sound that differs in frequency or duration. Many studies have shown that patients with schizophrenia are impaired in this process. Moreover, there is evidence that MMN-deficits may be present in early-stage psychosis.  To investigate this possibility, we employed Magnetoencephalography (MEG) to establish whether MMN-responses are impaired in participants at 116 Clinical High Risk for psychosis and 33 First Episode Psychosis Patients compared with 38 psychiatric controls and 49 healthy controls. Contrary to our hypothesis, MMN-responses were intact, suggesting that MMN may not constitute a biomarker for early detection and diagnosis of psychosis.

Reference:

[1] Pradeep D, et. al., "Intact Mismatch Negativity Responses in Clinical High-Risk for Psychosis and First-Episode Psychosis: Evidence from Source-Reconstructed Event-Related Fields and Time-Frequency Data", Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, (2023)

https://www.biologicalpsychiatrycnni.org/article/S2451-9022(23)00244-6/fulltext