Is the iron dysregulated in the mirror neuron system in misophonia?
In my latest paper, we hypothesize that in Misophonia (a condition characterized by intense emotional and physiological reactions to specific human-generated sounds) there is a self-perpetuating cycle of mirror system hyperactivity mediated by iron dysregulation. Here is the predicted pathological self-perpetuating cycle: Mirror system hyperactivity → Metabolic stress → Iron accumulation → Inflammation → Impaired inhibition → Involuntary mimicry. We suggest that therapies aimed at breaking this self-perpetuating loop may offer effective strategies for managing Misophonia. Reference : [1] Pradeep Dheerendra, Soumita Ramesh, "Is iron dysregulation in the mirror motor cortex associated with misophonia?", Medical Hypotheses, vol. 204, p. 111765, Nov 2025. https://doi.org/10.1016/j.mehy.2025.111765 Abstract : Iron homeostasis plays a critical role in brain function and mental health, yet its dysregulation in specific psychiatric conditions remains underexplored. In this ...